The aim of this ESR project is to investigate and develop an innovative and sustainable AiPBAND business model in order to adequately address the social-economic dimensions in the development of an integrated cloud based brain cancer diagnostic system. Relationships between business model qualifying factors (such as value, cost structure, potential revenue sources) and enabling factors (including entrepreneurial attributes, market uptake evaluation, business dynamics and sustainability) will be investigated, so that the innovative AiPBAND business model will be market-oriented, resilient, robust and sustainable to guide business strategy development. In order to achieve the overall aim, three key objectives have been identified. To address the entrepreneurial attributes through investigating business planning, valuing and financing, IPR and patent management, and commercialising based on the definition of an AiPBAND matrix integrating entrepreneurial knowledge, skills and competence. To address market uptake evaluation by exploring a multi-criteria decision-making framework through comparative analysis to take account of all stakeholders’ preferences and concerns, to coherently evaluate the market opportunities and risks of the AiPBAND integrated platform. To address business dynamics and sustainability by investigating the dynamics of AiPBAND business environment and potential changes, so that long-term business sustainability can be maintained.